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David R Beier Selected Research

Cystic Kidney Diseases (Cystic Kidney Disease)

1/2016High-resolution genetic localization of a modifying locus affecting disease severity in the juvenile cystic kidneys (jck) mouse model of polycystic kidney disease.
1/2016Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis.
1/2015ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning.
1/2013Loss of the ciliary kinase Nek8 causes left-right asymmetry defects.
3/2008Nek8 regulates the expression and localization of polycystin-1 and polycystin-2.
12/2002A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish.

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David R Beier Research Topics

Disease

6Cystic Kidney Diseases (Cystic Kidney Disease)
01/2016 - 12/2002
5Polycystic Kidney Diseases (Polycystic Kidney Disease)
01/2016 - 02/2002
3Cysts
10/2010 - 12/2002
2Cardiomyopathies (Cardiomyopathy)
05/2009 - 03/2005
1Hyperphagia (Overeating)
01/2016
1Alzheimer Disease (Alzheimer's Disease)
03/2015
1Ciliopathies
08/2013
1Fasciculation (Fasciculations)
02/2013
1Respiratory Hypersensitivity
08/2011
1Infections
12/2010
1Crush Injuries
10/2010
1Acute Kidney Injury (Acute Renal Failure)
10/2010
1Cleft Palate (Palate, Cleft)
03/2010
1Muscular Dystrophies (Muscular Dystrophy)
12/2009
1Fibrosis (Cirrhosis)
12/2009
1Paralysis (Palsy)
09/2009
1Glioblastoma (Glioblastoma Multiforme)
04/2008
1Cataract (Cataracts)
03/2008
1Waardenburg Syndrome (Klein Syndrome)
06/2007
1Metrorrhagia (Spotting)
06/2007
1Atherosclerosis
10/2002

Drug/Important Bio-Agent (IBA)

5Proteins (Proteins, Gene)FDA Link
04/2008 - 02/2002
4Phosphotransferases (Kinase)IBA
01/2015 - 03/2008
4Ethylnitrosourea (N-Ethyl-N-nitrosourea)IBA
03/2010 - 06/2007
2Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
01/2016 - 03/2008
1RoscovitineIBA
01/2016
1Pro-Opiomelanocortin (Proopiomelanocortin)IBA
01/2016
1Amyloid (Amyloid Fibrils)IBA
03/2015
1Endoplasmic Reticulum Chaperone BiPIBA
02/2013
1AllergensIBA
08/2011
1DNA Transposable Elements (Element, IS)IBA
12/2010
1Gentamicins (Gentamicin)FDA LinkGeneric
10/2010
1Transforming Growth Factor beta (TGF-beta)IBA
12/2009
1Latent TGF-beta Binding Proteins (Latent TGF beta Binding Protein)IBA
12/2009
1Proline (L-Proline)FDA Link
12/2009
1Amino AcidsFDA Link
12/2009
1Endothelin-3 (Endothelin 3)IBA
06/2007
1MorpholinosIBA
12/2002
1NIMA-Related KinasesIBA
12/2002
1Antisense OligonucleotidesIBA
12/2002
1Messenger RNA (mRNA)IBA
10/2002
1AntioxidantsIBA
10/2002
1oxidized low density lipoproteinIBA
10/2002